Does Green Tea Induce Hormesis?

Green tea polyphenols induce differentiation and proliferation in epidermal keratinocytes.

The most abundant green tea polyphenol, epigallocatechin-3-gallate (EGCG), was found to induce differential effects between tumor cells and normal cells. Nevertheless, how normal epithelial cells respond to the polyphenol at concentrations for which tumor cells undergo apoptosis is undefined. The current study tested exponentially growing and aged primary human epidermal keratinocytes in respon...

Green tea: a tea or a remedy?

Green tea polyphenol sensing

Green tea polyphenols have emerged over the past two decades as an important dietary factor for health promotion. There is considerable evidence that tea polyphenols, in particular (-)-epigallocatechin-3-gallate (EGCG) inhibit carcinogenesis. However, the mechanisms for the cancer-preventive activity of EGCG are not completely characterized and many features remain to be elucidated. Recently we...

Green tea gets molecular.

Green tea and its major polyphenolic flavonoid, epigallocatechin gallate (EGCG), have been credited with cancer chemopreventive activity for many years; the mechanism for this activity, however, has remained obscure. Now, as reported in this issue of the journal (beginning on page 1366), Urusova and colleagues showed direct binding of EGCG to the peptidyl prolyl cis/trans isomerase Pin1, which ...

13 Green Tea

Over the past decade, teas and their molecular components have received increasing attention from researchers in human health. After water, tea is the most widely consumed and popular beverage in the world. It has a cooling effect, slightly bitter and astringent flavor which many is enjoyed by people and its medicinal properties have been widely explored. In addition, its content of certain min...